An internal standard for the quantification of zileuton by GC- or LC-MS

Zileuton-d4 – 1 mg

Brand:
Cayman
CAS:
1189878-76-9
Storage:
-20
UN-No:
Non-Hazardous - /

Zileuton-d4 is intended for use as an internal standard for the quantification of zileuton (Item No. 10006967) by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.{1367} It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4; Item No. 20110) production induced by the calcium ionophore A23187 (Item No. 11016) in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.{42699} Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.  

 

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SKU: 26761 - 1 mg Category:

Description

An internal standard for the quantification of zileuton by GC- or LC-MS

Formal name: N-(1-benzo[b]thien-2-ylethyl-d4)-N-hydroxy-urea

Synonyms: 

Molecular weight: 240.3

CAS: 1189878-76-9

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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