A reversible 5-LO inhibitor; inhibits 5-LO activity in RBL-1 cell supernatant (IC50 = 0.5 µM); inhibits LTB4 production induced by A23187 in purified human PMNLs (IC50 = 0.6 µM); prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge at 10 mg/kg

Zileuton – 5 mg

Brand:
Cayman
CAS:
111406-87-2
Storage:
-20
UN-No:
Non-Hazardous - /

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.{1367} It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4; Item No. 20110) production induced by the calcium ionophore A23187 (Item No. 11016) in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.{42699} Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.  

 

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SKU: 10006967 - 5 mg Category:

Description

A reversible 5-LO inhibitor; inhibits 5-LO activity in RBL-1 cell supernatant (IC50 = 0.5 µM); inhibits LTB4 production induced by A23187 in purified human PMNLs (IC50 = 0.6 µM); prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge at 10 mg/kg, p.o., 2 hours pre-challenge

Formal name: N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea

Synonyms:  A 64077

Molecular weight: 236.3

CAS: 111406-87-2

Purity: >98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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