A carotenoid with hepatoprotective activity; inhibits TGF-β-induced activation of hepatic stellate cells (IC50 = 186.34 µM); reduces hepatic collagen deposition and TBARS levels

Zeaxanthin Dipalmitate – 1 mg

Brand:
Cayman
CAS:
144-67-2
Storage:
-20
UN-No:
Non-Hazardous - /

Zeaxanthin dipalmitate is a carotenoid that has been found in F. lycii and has hepatoprotective activity.{59530,59531,59532,59533} It inhibits TGF-β-induced activation of hepatic stellate cells (IC50 = 186.34 µM).{59531} Zeaxanthin (25 mg/kg) reduces hepatic collagen deposition and levels of thiobarbituric acid reactive substances (TBARS), as well as the activity of serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP), in a rat model of hepatic fibrosis induced by bile duct ligation.{59532} It also decreases reactivated levels of hepatitis B virus (HBV) DNA and reduces hepatic steatosis, inflammation, and fibrosis in a model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient diet in HBV transgenic mice.{59533}  

 

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SKU: 31703 - 1 mg Category:

Description

A carotenoid with hepatoprotective activity; inhibits TGF-β-induced activation of hepatic stellate cells (IC50 = 186.34 µM); reduces hepatic collagen deposition and TBARS levels, as well as serum AST and ALP activity, in a rat model of bile duct ligation-induced hepatic fibrosis at 25 mg/kg; reduces hepatic steatosis, inflammation, and fibrosis in a model of NASH induced by a methionine choline-deficient diet in HBV transgenic mice

Formal name: (3R,3′R)-β,β-carotene-3,3′-diol, 3,3′-dihexadecanoate

Synonyms:  Physalien

Molecular weight: 1,045.70

CAS: 144-67-2

Purity: ≥95%

Formulation: A crystalline solid

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