A mycotoxin; binds to human ERα and ERβ (IC50s = 9 and 5.8 nM

Zearalenone – 5 mg

Brand:
Cayman
CAS:
17924-92-4
Storage:
-20
UN-No:
De Minimis - 3261 / 8

Zearalenone is a mycotoxin that has been found in Fusarium and has estrogenic activities.{20562} It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).{54526} Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.{20560} Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also induces degeneration of meiotic chromatin in oocytes and reduces fertility in pigs when administered at a dose of 200 µg/kg.{20561} Zearalenone has been found as a contaminant in wheat, maize, and barley and livestock feeds.{20560,20561}  

 

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SKU: 11353 - 5 mg Category:

Description

A mycotoxin; binds to human ERα and ERβ (IC50s = 9 and 5.8 nM, respectively); induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs; induces hyperestrogenism in pigs from 1.5-5 mg/kg; has been found as a contaminant in wheat, maize, and barley and livestock feeds

Formal name: (3S,11E)-3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Synonyms:  FES|Mycotoxin F2|Toxin F2|Zenone

Molecular weight: 318.4

CAS: 17924-92-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Toxicology|Environmental|Agriculture||Research Area|Toxicology|Environmental|Endocrine Disruption

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