A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM

ZD 7288 – 10 mg

Brand:
Cayman
CAS:
133059-99-1
Storage:
-20
UN-No:
Non-Hazardous - /

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability.{28047} Certain HCN channels also accentuate neuropathic pain.{28043} ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).{28045} Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.{28049,28044} In addition, ZD 7288 reduces neuropathic pain in several animal models.{28046,28048}  

 

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Description

A potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively); modulates the sinoatrial node and slows heart rate; reduces neuropathic pain in several animal models

Formal name: N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride

Synonyms:  ICI-D 7288

Molecular weight: 292.8

CAS: 133059-99-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Neuroscience|Pain Research

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