A cell-permeable inhibitor of Cdc42

ZCL 278 – 50 mg

Brand:
Cayman
CAS:
587841-73-4
Storage:
-20
UN-No:
Non-Hazardous - /

ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase.{32673} It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).{32673} It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively.{32673} ZCL 278 also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.{32672}  

 

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Description

A cell-permeable inhibitor of Cdc42, blocking interaction with the GEF intersectin; exhibits antiviral activity by blocking cellular entry and inhibiting viral replication

Formal name: 2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide

Synonyms: 

Molecular weight: 584.9

CAS: 587841-73-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases||Research Area|Neuroscience

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