A pyrimidine analog derived from deoxycytidine that acts as a substrate for HIV reverse transcriptase (Ki = 51 nM) and inhibits replication of HIV

Zalcitabine – 100 mg

Brand:
Cayman
CAS:
7481-89-2
Storage:
-20
UN-No:
Non-Hazardous - /

Zalcitabine is an analog of pyrimidine derived from deoxycytidine with the replacement of the hydroxyl group in position 3’ with a hydrogen.{8362} In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM).{26225,26224} It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. Zalcitabine was the third antiretroviral approved by the FDA for treatment of HIV infection and AIDS.{24196}  

 

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Description

A pyrimidine analog derived from deoxycytidine that acts as a substrate for HIV reverse transcriptase (Ki = 51 nM) and inhibits replication of HIV

Formal name: 2′,3′-dideoxy-cytidine

Synonyms:  2’,3’-Dideoxycytidine|ddC|Hivid|NSC 606170|Ro 24-2027/000

Molecular weight: 211.2

CAS: 7481-89-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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