A T-type calcium channel inhibitor (IC50s = 0.050-0.160 µM for human recombinant Cav3.1

Z944 – 5 mg

Brand:
Cayman
CAS:
1199236-64-0
Storage:
-20
UN-No:
Non-Hazardous - /

Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 µM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3).{52410} It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 µM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 µM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.{52411}  

 

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SKU: 27679 - 5 mg Category:

Description

A T-type calcium channel inhibitor (IC50s = 0.050-0.160 µM for human recombinant Cav3.1, Cav3.2, and Cav3.3); selective for T-type channels over the Cav2.2 channel (IC50 = 11 µM), as well as rat Cav1.2, hERG/Kv11.1, and human Nav1.5 channels (IC50s = 32, 7.8, and 100 µM, respectively); reduces seizure duration and the amount of time spent in seizures in a rat model of absence epilepsy at 30 mg/kg

Formal name: 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide

Synonyms: 

Molecular weight: 383.9

CAS: 1199236-64-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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