A cell-permeable

Z-VAD(OMe)-FMK – 1 mg

Brand:
Cayman
CAS:
187389-52-2
Storage:
-20
UN-No:
Non-Hazardous - /

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases.{22863,7777} Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM.{22863,22860} It also blocks caspase-mediated apoptosis in vivo.{22858} Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.{22859}  

 

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Description

A cell-permeable, competitive, and irreversible inhibitor of all caspases, inhibiting cleavage of PARP and preventing apoptosis when used at 10-50 µM; blocks caspase-mediated apoptosis in vivo; effectively prevents caspase action in inflammasomes

Formal name: N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide

Synonyms:  Z-Val-Ala-Asp-(OMe)-Fluoromethyl Ketone

Molecular weight: 467.5

CAS: 187389-52-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation

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