Description
An inhibitor of cathepsin L (Kinact = 200,000 M-1s-1); selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively); active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 μM)
Formal name: N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester
Synonyms: Cbz-Phe-Tyr(O-t-Bu)-CHN2|Z-Phe-Tyr(tBu)-CHN2
Molecular weight: 542.6
CAS: 114014-15-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness
