A phthalide with diverse biological activities; inhibits autophagy and restores Nurr77 expression and tamoxifen sensitivity in tamoxifen-resistant MCF-7 cells; increases cerebral expression of Nrf2 and HO-1 and reduces infarct volume and neuronal loss in a rat model of cerebral ischemia and reperfusion injury from 8-32 mg/kg; decreases mechanical and thermal hyperalgesia in a rat model of CFA-induced inflammatory pain; restores gait coordination

(Z)-Ligustilide – 100 mg

Brand:
Cayman
CAS:
81944-09-4
Storage:
-20
UN-No:
- 1170 / 3

(Z)-Ligustilide is a phthalide that has been found in A. graveolens and T. montana roots and has diverse biological activities.{48404,48405,48406,48407} It inhibits autophagy and restores Nurr77 expression and sensitivity to tamoxifen (Item No. 13258) in tamoxifen-resistant MCF-7 cells.{48405} (Z)-Ligustilide (8-32 mg/kg) increases cerebral expression of Nrf2 and HO-1 and reduces infarct volume and neuronal loss in a rat model of cerebral ischemia and reperfusion injury.{48408} It decreases mechanical and thermal hyperalgesia in a rat model of inflammatory pain induced by complete Freund’s adjuvant (CFA).{48406} (Z)-Ligustilide restores gait coordination, reduces spinal cord inducible nitric oxide synthase (iNOS) expression, and inhibits production of prostaglandin E2 (PGE2; Item No. 14010), TNF-α, and IL-1β in a rat model of spinal cord injury.{48407}  

 

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Description

A phthalide with diverse biological activities; inhibits autophagy and restores Nurr77 expression and tamoxifen sensitivity in tamoxifen-resistant MCF-7 cells; increases cerebral expression of Nrf2 and HO-1 and reduces infarct volume and neuronal loss in a rat model of cerebral ischemia and reperfusion injury from 8-32 mg/kg; decreases mechanical and thermal hyperalgesia in a rat model of CFA-induced inflammatory pain; restores gait coordination, reduces spinal cord iNOS mRNA expression, and inhibits production of PGE2, TNF-α, and IL-1β in a rat model of spinal cord injury

Formal name: 3Z-butylidene-4,5-dihydro-1(3H)-isobenzofuranone

Synonyms:  cis-Ligustilide|Ligustilide A

Molecular weight: 190.2

CAS: 81944-09-4

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Autophagy||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Neuroscience|Pain Research

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