A proteasome inhibitor with diverse biological activities; inhibits LPS-induced expression of FLT1 in isolated human microvascular endothelial cells and macrophages; reduces heat shock-induced increases in Hsp70 levels in neonatal rat cardiomyocytes at 1 µM; induces accumulation of the UbG76V-GFP reporter in and apoptosis of growth plate chondrocytes

Z-Leu-Leu-Leu-B(OH)2 – 200 µg

Brand:
Cayman
CAS:
179324-22-2
Storage:
-20
UN-No:
Non-Hazardous - /

Z-Leu-Leu-Leu-B(OH)2 is a proteasome inhibitor with diverse biological activities.{49657,49658,49659} It inhibits LPS-induced expression of FMS-related tyrosine kinase 1 (FLT1) in isolated human microvascular endothelial cells and macrophages.{49657} Z-Leu-Leu-Leu-B(OH)2 (1 µM) reduces heat shock-induced increases in heat shock protein 70 (Hsp70) levels in neonatal rat cardiomyocytes.{49658} In vivo, Z-Leu-Leu-Leu-B(OH)2 (1 µmol/kg) induces accumulation of the UbG76V-GFP reporter, which is constitutively targeted for ubiquitin-dependent proteasomal degradation, in and apoptosis of growth plate chondrocytes, as well as growth retardation in mice.{49659}  

 

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Description

A proteasome inhibitor with diverse biological activities; inhibits LPS-induced expression of FLT1 in isolated human microvascular endothelial cells and macrophages; reduces heat shock-induced increases in Hsp70 levels in neonatal rat cardiomyocytes at 1 µM; induces accumulation of the UbG76V-GFP reporter in and apoptosis of growth plate chondrocytes, as well as growth retardation in mice at 1 µmol/kg

Formal name: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-borono-3-methylbutyl]-L-leucinamide

Synonyms:  MG 262

Molecular weight: 491.4

CAS: 179324-22-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Immunology & Inflammation|Innate Immunity

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