An irreversible inhibitor of cysteine proteases

Z-FA-FMK – 5 mg

Brand:
Cayman
CAS:
197855-65-5
Storage:
-20
UN-No:
Non-Hazardous - /

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain.{22853} It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 µM) without affecting the initiator caspases-8 and -10.{22857} Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses.{22854,22856,22855} It can be used both in cells and in vivo.{22856,22855}  

 

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Description

An irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain; inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 µM) without affecting the initiator caspases-8 and -10; can be used both in cells and in vivo

Formal name: N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester

Synonyms:  Z-Phe-Ala-Fluoromethyl Ketone

Molecular weight: 386.4

CAS: 197855-65-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases

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