A pan-caspase inhibitor that blocks apoptosis

Z-Asp-CH2-DCB – 5 mg

Brand:
Cayman
CAS:
153088-73-4
Storage:
-20
UN-No:
Non-Hazardous - /

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3.{24224,24223} Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity.{24223} At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.{24222}  

 

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Description

A pan-caspase inhibitor that blocks apoptosis, prevents the production of cytokines, and inhibits T cell proliferation dose-dependently at 1-100 μM

Formal name: (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid

Synonyms:  Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone

Molecular weight: 454.3

CAS: 153088-73-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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