An irreversible inhibitor of caspase-10 and related caspases that at 10 µM prevents Bid cleavage into its active form

Z-AEVD-FMK – 500 µg

Brand:
Cayman
CAS:
1135688-47-9
Storage:
-20
UN-No:
Non-Hazardous - /

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.{25869} At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.{25870}  

 

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Description

An irreversible inhibitor of caspase-10 and related caspases that at 10 µM prevents Bid cleavage into its active form, caspase cascade activation, and apoptosis in Jurkat T lymphoma cells

Formal name: methyl-14S-(2-fluoroacetyl)-11S-isopropyl-8S-(3-methoxy-3-oxopropyl)-5S-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Synonyms:  Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Molecular weight: 610.6

CAS: 1135688-47-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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