A major phase I metabolite of tamoxifen

(Z)-4-hydroxy Tamoxifen – 25 mg

Brand:
Cayman
CAS:
68047-06-3
Storage:
-20
UN-No:
Non-Hazardous - /

(Z)-4-hydroxy Tamoxifen is a major phase I metabolite of tamoxifen (Item No. 13258), a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. (Z)-4-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity.{31466,28446,31468} The (Z), or trans, isomer of 4-hydroxytamoxifen has at least a 100-fold higher affinity for estrogen receptors than tamoxifen.{31894}  

 

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Description

A major phase I metabolite of tamoxifen, a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; has at least a 100-fold higher affinity for estrogen receptors than tamoxifen

Formal name: 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

Synonyms:  trans-4-hydroxy Tamoxifen|ICI 79280

Molecular weight: 387.5

CAS: 68047-06-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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