A small molecule CD4 mimetic; inhibits gp120 and CD4 interaction

YYA-021 – 1 mg

Brand:
Cayman
CAS:
144217-65-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

YYA-021 is a small molecule CD4 mimetic that competitively inhibits gp120 from interacting with CD4, preventing HIV entry into cells.{40117} It inhibits infection of PM1/CCR5 cells from lab isolates of the HIV-1 strains IIIB (X4, Sub B) and 89.6 (dual, Sub B) (IC50s = 23 and 41 µM, respectively) as well as clinical isolates of the fTOI (R5, Sub B) and KYAG strains (R5, Sub B) (IC50s = 16 and 51 µM, respectively). It also inhibits HIV-1 infection of TZM-bl cells (IC50 = 8.4 µM) and reduces viability of mock-infected PM1/CCR5 cells with cytotoxic concentration (CC50) values of 260 µM.{40116}  

 

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SKU: 22915 - 1 mg Category:

Description

A small molecule CD4 mimetic; inhibits gp120 and CD4 interaction, preventing HIV from entering cells; inhibits infection of PM1/CCR5 cells from lab isolates of the HIV-1 strains IIIB (X4, Sub B) and 89.6 (dual, Sub B) (IC50s = 23 and 41 µM, respectively); inhibits infection of PM1/CCR5 cells from clinical isolates of the fTOI (R5, Sub B) and KYAG strains (R5, Sub B) (IC50s = 16 and 51 µM, respectively); inhibits HIV-1 infection of TZM-bl cells (IC50 = 8.4 µM); reduces viability of mock-infected PM1/CCR5 cells with cytotoxic concentration (CC50) values of 260 µM

Formal name: N1-(4-methylphenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide

Synonyms: 

Molecular weight: 317.4

CAS: 144217-65-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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