Description
YTH domain containing 2 (YTHDC2) is an ATP-dependent 3’-5’ RNA helicase and a member of the DExD/H-box family of helicases.{42792} YTHDC2 contains ATP binding, ATP hydrolysis, and RNA binding motifs.{42792} The aYTH domain binds to N6-methyladenosine-modified germline messenger RNA to regulate meiotic gene expression in mammalian germ cells, mediating the mitotic-to-meiotic transition in mouse germ cells.{42795,42794} Ythdc2-/- male and female mice show disrupted meiotic prophase progression.{42794} Male Ythdc2-/- mice have degraded germ cells and lack mature spermatozoa, while female Ythdc2-/- mice lack developing ovarian follicles and have few germ cells. YTHDC2 also facilitates hepatitis C virus (HCV) genome replication by binding to the HCV replication cofactor cyclophilin B and the HCV RNA polymerase non-structural protein 5B (NS5B).{42793} YTHDC2 downregulation inhibits proliferation in Huh7 hepatocellular carcinoma cells and reduces metastasis a Y2KD-116 mouse xenograft model using HCT116 cells in which YTHDC2 is downregulated.{42793,35924} The expression of YTHDC2 in isolated human tumor tissue is positively correlated with tumor stage and lymph node metastasis.{35924} Cayman’s YTHDC2 Polyclonal Antibody can be used for immunofluorescence, immunohistochemistry, and Western blot applications. The antibody recognizes YTHDC2 at 160 kDa from human samples.
Synonyms: 3′-5′ RNA Helicase YTHDC2|hYTHDC2|YTH Domain-containing Protein 2
Immunogen: Full-length recombinant human YTHDC2 protein
Formulation: 500 µg of protein A-purified polyclonal antibody
Isotype:
Applications: IF, IHC and WB
Origin:
Stability: 365 days
Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Cell Cycle||Research Area|Endocrinology & Metabolism|Reproductive Biology
