A platelet aggregation inhibitor; inhibits ADP-

YS-49 – 5 mg

Brand:
Cayman
CAS:
132836-42-1
Storage:
-20
UN-No:
Non-Hazardous - /

YS-49 is an inhibitor of platelet aggregation.{53944} It inhibits ADP-, collagen-, or epinephrine-induced platelet aggregation in isolated human platelets (IC50s = 730, 92, and 3.4 µM, respectively). YS-49 also inhibits platelet aggregation and production of thromboxane A2 (TXA2) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in isolated rat platelets (IC50s = 3.3 and 32.8 µM, respectively).{53945} It reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner.{53946} YS-49 (50 mg/kg) decreases thrombus weight in a rat model of arterio-venous shunt thrombosis.{53944} It increases survival in a mouse model of septicemia induced by LPS when administered at doses of 10 and 20 mg/kg.{53946}  

 

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Description

A platelet aggregation inhibitor; inhibits ADP-, collagen-, or epinephrine-induced platelet aggregation in isolated human platelets (IC50s = 730, 92, and 3.4 µM, respectively); inhibits arachidonic acid-induced platelet aggregation and TXA2 production in isolated rat platelets (IC50s = 3.3 and 32.8 µM, respectively); reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner; decreases thrombus weight in a rat model of arterio-venous shunt thrombosis at 50 mg/kg; increases survival in a mouse model of septicemia induced by LPS at 10 and 20 mg/kg

Formal name: 1,2,3,4-tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol, monohydrobromide

Synonyms: 

Molecular weight: 386.3

CAS: 132836-42-1

Purity: ≥98%

Formulation: A crystalline solid

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