A non-competitive antagonist of mGluR1 (Ki = 19 nM); selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM

YM-298198 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
1216398-09-2
Storage:
-20
UN-No:
Non-Hazardous - /

YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1; Ki = 19 nM).{38955} It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20 nM). In vivo, YM-298198 (10 and 30 mg/kg, p.o.) increases nociceptive response latency in a mouse model of hyperalgesia induced by streptozotocin (Item No. 13104) without affecting motor coordination in a rotarod test. YM-298198 also reduces reinstatement of drug-seeking behavior induced by cocaine priming in rats.{38956}  

 

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Description

A non-competitive antagonist of mGluR1 (Ki = 19 nM); selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 μM, respectively); increases nociceptive response latency in a mouse model of streptozotocin-induced hyperalgesia (10 and 30 mg/kg, p.o.); reduces reinstatement of drug-seeking behavior induced by cocaine priming in rats,

Formal name: 6-amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide, monohydrochloride

Synonyms: 

Molecular weight: 378.9

CAS: 1216398-09-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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