An anticancer agent; inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s = 0.0858 and 4.2 µM

YL-109 – 10 mg

Brand:
Cayman
CAS:
36341-25-0
Storage:
-20
UN-No:
Non-Hazardous - /

YL-109 is an anticancer agent.{52496} It inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s = 0.0858 and 4.2 µM, respectively), as well as migration and invasion by MDA-MB-231 cells in vitro. It induces expression of carboxyl terminus of Hsp70-interacting protein (CHIP) in MDA-MB-231 cells in an AHR-dependent manner. YL-109 (1 µM) inhibits MDA-MB-231-derived cancer stem cell (CSC) mammosphere formation. In vivo, YL-109 (15 mg/kg) reduces tumor volume and the number of metastases in an MDA-MB-231 mouse xenograft model.  

 

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SKU: 30290 - 10 mg Category:

Description

An anticancer agent; inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s = 0.0858 and 4.2 µM, respectively), as well as migration and invasion by MDA-MB-231 cells in vitro; induces expression of CHIP in MDA-MB-231 cells in an AHR-dependent manner; inhibits MDA-MB-231-derived CSC mammosphere formation at 1 µM; reduces tumor volume and the number of metastases in an MDA-MB-231 mouse xenograft model at 15 mg/kg

Formal name: 4-(2-benzothiazolyl)-2-methoxy-phenol

Synonyms: 

Molecular weight: 257.3

CAS: 36341-25-0

Purity: ≥98%

Formulation: A crystalline solid

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