An inhibitor of tubulin polymerization and an activator of SIRT1; inhibits colchicine binding to tubulin and tubulin polymerization (IC50 = 31 μM); induces microtubule loss in A-10 cells (EC50 = 16.5 μM); inhibits cell growth in a panel of leukemia

YK-3-237 – 1 mg

Brand:
Cayman
CAS:
1215281-19-8
Storage:
-20
UN-No:
Non-Hazardous - /

YK-3-237 is a chalcone derivative and an activator of sirtuin 1 (SIRT1).{36848,36849} It inhibits colchicine binding to tubulin in a concentration-dependent manner and tubulin polymerization (IC50 = 31 μM) and induces microtubule loss in A-10 cells (EC50 = 16.5 μM).{36848} YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = 50s = 0.160-5.031 μM).  

 

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Description

An inhibitor of tubulin polymerization and an activator of SIRT1; inhibits colchicine binding to tubulin and tubulin polymerization (IC50 = 31 μM); induces microtubule loss in A-10 cells (EC50 = 16.5 μM); inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = 50s = 0.160-5.031 μM)

Formal name: B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid

Synonyms: 

Molecular weight: 372.2

CAS: 1215281-19-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Activators|Deacetylases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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