A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 μM; induces expression of FKBP51 and FGF18 in HEK293 cells at 10 μM; accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini; increases expression of the myogenic regulatory factors MyoD

YK-11 – 100 mg

Brand:
Cayman
CAS:
1370003-76-1
Storage:
-20
UN-No:
Non-Hazardous - /

YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.{48154} It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.{48155} YK-11 also accelerates proliferation and mineralization and increases expression of the osteoblast differentiation markers osteoprotegerin and osteocalcin in MC3T3-E1 mouse osteoblast cells.{48156}  

 

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SKU: 9003137 - 100 mg Category:

Description

A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 μM; induces expression of FKBP51 and FGF18 in HEK293 cells at 10 μM; accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini; increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as Fst, and induces myogenic differentiation in C2C12 cells at 500 nM; accelerates proliferation and mineralization and increases expression of osteoblast differentiation markers in MC3T3-E1 mouse osteoblast cells

Formal name: (20E)-17α,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 430.5

CAS: 1370003-76-1

Purity: ≥95% (mixture of diastereomers)

Formulation: A crystalline solid

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