A HAT activator; inhibits proliferation of CCRF-CEM

YF-2 – 1 mg

Brand:
Cayman
CAS:
1311423-89-8
Storage:
-20
UN-No:
Non-Hazardous - /

YF-2 is a histone acetyltransferase (HAT) activator.{53930} It inhibits proliferation of CCRF-CEM, Hs 578T, A549, and U251 cancer cells (IC50s = 88.7-286 µM), as well as multidrug-resistant NCI/ADR-RES cells (IC50 = 44.8 µM). YF-2 (5 mg/kg) increases reduced acetylated histone H3 levels in a mouse of model of Alzheimer’s disease induced by amyloid-β (1-42) (Aβ42; Item No. 20574). YF-2 (20 mg/kg) reduces contextual fear memory deficits in the transgenic APP/PS1 mouse model of Alzheimer’s disease.  

 

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SKU: 31230 - 1 mg Category:

Description

A HAT activator; inhibits proliferation of CCRF-CEM, Hs 578T, A549, U251, and NCI/ADR-RES cancer cells (IC50s = 44.8-286 µM); increases reduced acetylated histone H3 levels in a mouse of model of Alzheimer’s disease induced by Aβ42 at 5 mg/kg; reduces contextual fear memory deficits in the transgenic APP/PS1 mouse model of Alzheimer’s disease at 20 mg/kg

Formal name: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxy-benzamide

Synonyms: 

Molecular weight: 430.9

CAS: 1311423-89-8

Purity: ≥98%

Formulation: A crystalline solid

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