A lignan with diverse biological activities; inhibits CYP3A4 (IC50 = 1 μM); inhibits HSV-1 replication in a plaque reduction assay (IC50 = 30.6 μM); induces apoptosis and production of ROS in and is cytotoxic to A549 and CL1-5 NSCLC cells (IC50s = 3.5 and 1.9 μM

Yatein – 500 µg

Brand:
Cayman
CAS:
40456-50-6
Storage:
-20
UN-No:
Non-Hazardous - /

Yatein is a lignan that has been found in C. formosana and has diverse biological activities.{46751,46752,46753,46754} It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 μM).{46751} Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 μM).{46752} It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 μM, respectively).{46753} Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in a concentration-dependent manner.{46754}  

 

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Description

A lignan with diverse biological activities; inhibits CYP3A4 (IC50 = 1 μM); inhibits HSV-1 replication in a plaque reduction assay (IC50 = 30.6 μM); induces apoptosis and production of ROS in and is cytotoxic to A549 and CL1-5 NSCLC cells (IC50s = 3.5 and 1.9 μM, respectively); inhibits aggregation of rabbit platelets induced by PAF, collagen, or arachidonic acid in a concentration-dependent manner

Formal name: (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-2(3H)-furanone

Synonyms:  (–)-Yatein|Deoxypodorhizone

Molecular weight: 400.4

CAS: 40456-50-6

Purity: ≥98%

Formulation: A solid

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