A natural kavalactone that enhances the binding of bicuculline at the GABA receptor GABAA at 1.0 µM; binds the CB1 receptor with a Ki value of 0.72 µM; blocks the activation of NF-κB by TNF-α; inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL)

Yangonin – 5 mg

Brand:
Cayman
CAS:
500-62-9
Storage:
-20
UN-No:
Non-Hazardous - /

Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 µM.{25728} Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 µM, but whether it serves as an agonist or antagonist at this receptor remains to be determined.{25724} Yangonin blocks the activation of NF-κB by TNF-α.{25725} It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).{36099}  

 

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Description

A natural kavalactone that enhances the binding of bicuculline at the GABA receptor GABAA at 1.0 µM; binds the CB1 receptor with a Ki value of 0.72 µM; blocks the activation of NF-κB by TNF-α; inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL)

Formal name: 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one

Synonyms: 

Molecular weight: 258.3

CAS: 500-62-9

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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