An activator of KATP channels; increases the frequency of KATP channel openings in the presence of ATP and activates KATP channel currents in isolated human β-cells at 200 μM; inhibits increases in intracellular calcium induced by histamine or norepinephrine in isolated rabbit mesenteric artery smooth muscle in a concentration-dependent manner; induces relaxation in isolated precontracted rat aortic rings (IC50 = 0.027 μM); decreases mean blood pressure in spontaneously hypertensive rats when administered intravenously at 0.03 mg/kg

Y-26763 – 5 mg

Brand:
Cayman
CAS:
127408-31-5
Storage:
-20
UN-No:
- /

Y-26763 is an activator of ATP-sensitive potassium (KATP) channels.{50363} It increases the frequency of KATP channel openings in the presence of ATP and activates KATP channel currents in isolated human β-cells when used at a concentration of 200 μM. It also inhibits increases in intracellular calcium induced by histamine or norepinephrine (Item No. 16673) in isolated rabbit mesenteric artery smooth muscle in a concentration-dependent manner.{50364} Y-26763 induces relaxation in isolated precontracted rat aortic rings (IC50 = 0.027 μM).{50365} It decreases mean blood pressure in spontaneously hypertensive rats when administered intravenously at a dose of 0.03 mg/kg, an effect that can be reversed by glibenclamide (Item No. 15009).  

 

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Description

An activator of KATP channels; increases the frequency of KATP channel openings in the presence of ATP and activates KATP channel currents in isolated human β-cells at 200 μM; inhibits increases in intracellular calcium induced by histamine or norepinephrine in isolated rabbit mesenteric artery smooth muscle in a concentration-dependent manner; induces relaxation in isolated precontracted rat aortic rings (IC50 = 0.027 μM); decreases mean blood pressure in spontaneously hypertensive rats when administered intravenously at 0.03 mg/kg

Formal name: N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-acetamide

Synonyms: 

Molecular weight: 276.3

CAS: 127408-31-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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