A TNK2 inhibitor (IC50 = 1.9 μM in HEK293T cells expressing human TNK2); selective for TNK2 over a panel of ~100 kinases with >90

XMD8-87 – 1 mg

Brand:
Cayman
CAS:
1234480-46-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2.{37179} It is selective for TNK2 over a panel of approximately 100 kinases with >90 and 50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM).  

 

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SKU: 23354 - 1 mg Category:

Description

A TNK2 inhibitor (IC50 = 1.9 μM in HEK293T cells expressing human TNK2); selective for TNK2 over a panel of ~100 kinases with >90, and 50s = 0.1-77 nM) with no effect on cell expressing wild-type TNK2 (IC50 = >1 μM)

Formal name: 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Synonyms: 

Molecular weight: 445.5

CAS: 1234480-46-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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