An ester prodrug of melagatran

Ximelagatran – 500 µg

Brand:
Cayman
CAS:
192939-46-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM).{27703,27704} While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action.{27704} Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues.{27703,27704} It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.{27704,15996}  

 

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Description

An ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM); used as an anticoagulant in a variety of situations

Formal name: N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]-glycine, ethyl ester

Synonyms:  Exanta|H 376/95

Molecular weight: 473.6

CAS: 192939-46-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart|Arrhythmia

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