A natural prenylated chalcone that induces protective detoxification enzymes

Xanthohumol – 1 mg

Brand:
Cayman
CAS:
6754-58-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Xanthohumol is a natural prenylated chalcone isolated from the hop plant, H. lupulus. Xanthohumol and its metabolites induce protective detoxification enzymes, at least in part via the nuclear factor erythroid-2-related factor 2 pathway.{25297,25114} It inhibits phosphoinositide-dependent kinase 1 (IC50 = 6.6 μM) but not PKC in an in vitro assay.{25298} Xanthohumol also can have anti-inflammatory, antioxidant, anti-carcinogenic, and osteogenic effects.{25301,25300,25299}  

 

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Description

A natural prenylated chalcone that induces protective detoxification enzymes, at least in part via the Nrf2 pathway; inhibits PDK1 (IC50 = 6.6 μM) but not PKC in an in vitro assay; also can have anti-inflammatory, antioxidant, anti-carcinogenic, and osteogenic effects

Formal name: (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Synonyms: 

Molecular weight: 354.4

CAS: 6754-58-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation

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