Wy 14643 is a PPAR activator. Although this compound is primarily an activator of PPARα

Wy 14643 – 10 mg

Brand:
Cayman
CAS:
50892-23-4
Storage:
22
UN-No:
Non-Hazardous - /

Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,{3458,6573,6549} it activates PPARγ as well.{4044} Activation of PPARδ by Wy 14643 is also observed,{6161} but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.{5592}  

 

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Description

Wy 14643 is a PPAR activator. Although this compound is primarily an activator of PPARα,{3458,6573,6549} it activates PPARγ as well.{4044} Activation of PPAR.delta. by Wy 14643 is also observed,{6161} but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.{5592}

Formal name: [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid

Synonyms:  Pirinixic Acid

Molecular weight: 323.8

CAS: 50892-23-4

Purity: ≥98%

Formulation: A crystalline solid

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