A brain-penetrant

WWL123 – 5 mg

Brand:
Cayman
CAS:
1338574-83-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (Item No. 62160) to regulate its availability at cannabinoid receptors.{15253} WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 µM) that demonstrates >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases.{27126} Inhibition of ABHD6 by WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models.{27125}  

 

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Description

A brain-penetrant, selective inhibitor of ABHD6 (IC50 = 0.43 µM) that has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models

Formal name: N-([1,1′-biphenyl]-3-ylmethyl)-N-methyl-carbamic acid, 4′-(aminocarbonyl)[1,1′-biphenyl]-4-yl ester

Synonyms: 

Molecular weight: 436.5

CAS: 1338574-83-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Seizure Disorders

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