A compound that stimulates the proliferation of pancreatic β cells rodent and human primary islets (ECmax = 200 and 400 nM

WS6 – 10 mg

Brand:
Cayman
CAS:
1421227-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

WS6 is a compound that stimulates the proliferation of pancreatic β cells in rodent and human primary islets (ECmax = 200 and 400 nM, respectively, over four days).{32144,32143} It promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.{32144} WS6 also stimulates α cell proliferation in human pancreatic islets.{32142} WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.{32144}  

 

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Description

A compound that stimulates the proliferation of pancreatic β cells rodent and human primary islets (ECmax = 200 and 400 nM, respectively, over four days); promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation

Formal name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide

Synonyms: 

Molecular weight: 568.6

CAS: 1421227-53-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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