A flavonoid with anti-inflammatory and anticancer activities; an active metabolite of wogonin; decreases colonic pathological damage and myeloperoxidase and iNOS activity

Wogonoside – 25 mg

Brand:
Cayman
CAS:
51059-44-0
Storage:
-20
UN-No:
Non-Hazardous - /

Wogonoside is an active metabolite of wogonin (Item No. 14248) and a flavonoid that has been found in S. baicalensis and has anti-inflammatory and anticancer activities.{49413,49419,49420} It decreases the levels of IL-1β, TNF-α, and IL-6 and inhibits the activation of NF-κB and the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{49413} Wogonoside (25 and 50 mg/kg) decreases colonic pathological damage and the activity of myeloperoxidase and inducible nitric oxide synthase (iNOS), as well as inhibits NF-κB and NLRP3 inflammasome activation in the colon in a mouse model of colitis induced by dextran sulfate sodium (Item No. 23250). It inhibits phosphorylation of the mammalian target of rapamycin (mTOR), as well as inhibits the growth of (IC50 = 133.9 µM), and induces autophagy in, MDA-MB-231 breast cancer cells.{49419} Wogonoside (50-100 µM) inhibits tube formation by human umbilical vein endothelial cells (HUVECs) and increases Wnt3a levels and β-catenin phosphorylation in MCF-7 cells and reduces tumor growth and angiogenesis in an MCF-7 mouse xenograft model when administered at a dose of 80 mg/kg.{49420}  

 

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Description

A flavonoid with anti-inflammatory and anticancer activities; an active metabolite of wogonin; decreases colonic pathological damage and myeloperoxidase and iNOS activity, as well as inhibits NF-κB and NLRP3 inflammasome activation in a DSS-induced mouse model of colitis at 25 and 50 mg/kg; inhibits phosphorylation of mTOR, as well as inhibits the growth of (IC50 = 133.9 µM), and induces autophagy in, MDA-MB-231 breast cancer cells; inhibits tube formation by HUVECs, increases Wnt3a levels and β-catenin phosphorylation in MCF-7 cells at 50-100 µM; reduces tumor growth and angiogenesis in an MCF-7 mouse xenograft model at 80 mg/kg

Formal name: 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid

Synonyms:  Wogonin 7-O-β-D-Glucuronide|Wogonin 7-β-D-Glucuronide

Molecular weight: 460.4

CAS: 51059-44-0

Purity: ≥98%

Formulation: A solid

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