A cell-permeable activator of Wnt signaling that does not inhibit GSK-3β (IC50 > 60 µM); induces nuclear accumulation of β-catenin

Wnt Agonist I – 25 mg

Brand:
Cayman
CAS:
853220-52-7
Storage:
-20
UN-No:
Non-Hazardous - /

Wnt Agonist I is a cell-permeable activator of Wnt signaling that does not inhibit GSK-3β (IC50 > 60 µM).{32213} It induces nuclear accumulation of β-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM) and altering embryonic development.{32213,32212} Wnt Agonist I is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats.{32211}  

 

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Description

A cell-permeable activator of Wnt signaling that does not inhibit GSK-3β (IC50 > 60 µM); induces nuclear accumulation of β-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM)

Formal name: N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine

Synonyms:  BML-284

Molecular weight: 350.4

CAS: 853220-52-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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