A cell-permeable

Wiskostatin – 10 mg

Brand:
Cayman
CAS:
253449-04-6
Storage:
-20
UN-No:
Non-Hazardous - /

Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex.{23890} As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking.{23889} Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 μM).{23889} It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.{23889} By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.{23891,23887,23888}  

 

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Description

A cell-permeable, selective inhibitor of N-WASP (IC50 = ~10 μM); directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and PIP2; interferes with membrane transport, endocytosis, and neurological development

Formal name: 3,6-dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol

Synonyms: 

Molecular weight: 426.1

CAS: 253449-04-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Neuroscience

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