An aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor

(-)-WIN 55,212-3 (mesylate) – 5 mg

Brand:
Cayman
CAS:
131543-25-4
Storage:
-20
UN-No:
Non-Hazardous - /

(−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 (pA2 = 6.1) and the inverse agonism of SR 144528 (Item No. 9000491) (pEC50 = 5.3).{13290} (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ9-THC on rat cerebellar membranes, which presumably express the CB1 receptor.{16960,16963} (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors.{13290}  

 

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SKU: 12022 - 5 mg Category:

Description

An aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 (pA2 = 6.1) and the inverse agonism of SR 144528 (pEC50 = 5.3)

Formal name: [(3S)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, methanesulfonate

Synonyms: 

Molecular weight: 522.6

CAS: 131543-25-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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