A potent aminoalkylindole CB receptor agonist (Ki = 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors

(+)-WIN 55,212-2 (mesylate) – 25 mg

Brand:
Cayman
CAS:
131543-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.{5240} In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve.{14361} This effect is fully counteracted by rimonabant (Item No. 9000484) at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C (Item No. 64950) at a concentration of 1 µM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 µM.{14362}  

 

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SKU: 10009023 - 25 mg Category:

Description

A potent aminoalkylindole CB receptor agonist (Ki = 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively); increases extracellular glutamate levels in primary cultures of rat cerebral cortex neurons, displaying a bell-shaped concentration-response curve; induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion neurons in a calcium-dependent manner (EC50 = 26 µM)

Formal name: [(3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone, monomethanesulfonate

Synonyms: 

Molecular weight: 522.6

CAS: 131543-23-2

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Neuroendocrinology

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