Inhibits aldehyde dehydrogenase 1a2

WIN 18,446 – 250 mg

Brand:
Cayman
CAS:
1477-57-2
Storage:
-20
UN-No:
Non-Hazardous - /

WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism.{23122} In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis.{23123,23122} As a result, WIN 18,446 may cause infertility in males.{23123,23122}  

 

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Description

Inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism; suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis

Formal name: N,N’-1,8-octanediylbis[2,2-dichloro-acetamide]

Synonyms:  NSC 59354

Molecular weight: 366.1

CAS: 1477-57-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Reproductive Biology

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