A negative control for JAK3 inhibition; molecular modeling estimated a Ki value of 72 µM; inactive at JAK3 (IC50 = >300 µM)

WHI-P258 – 5 mg

Brand:
Cayman
CAS:
21561-09-1
Storage:
-20
UN-No:
Non-Hazardous - /

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 µM.{16507} However, it is inactive at JAK3 (IC50 = >300 µM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.{40398,40397}  

 

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SKU: 23453 - 5 mg Category:

Description

A negative control for JAK3 inhibition; molecular modeling estimated a Ki value of 72 µM; inactive at JAK3 (IC50 = >300 µM)

Formal name: 6,7-dimethoxy-N-phenyl-4-quinazolinamine

Synonyms: 

Molecular weight: 281.3

CAS: 21561-09-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Negative Controls||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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