An mTOR inhibitor (IC50 = 0.009 µM); selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM

WAY-600 – 5 mg

Brand:
Cayman
CAS:
1062159-35-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

WAY-600 is an inhibitor of mammalian target of rapamycin (mTOR; IC50 = 0.009 µM).{52139} It selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM, respectively) and 24 additional lipid and protein kinases in a panel (IC50s = >50 µM for all). WAY-600 decreases phosphorylation of the mTORC1 and mTORC2 substrates Akt and S6 kinase (S6K1), respectively, in a cell-free assay when used at concentrations of 0.2, 1, and 5 µM. It decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells, with IC50 values ranging from 0.6 to 2.5 µM. WAY-600 reduces tumor growth in a HepG2 mouse xenograft model when administered at a dose of 10 mg/kg for 14 days.{52140}  

 

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SKU: 29214 - 5 mg Category:

Description

An mTOR inhibitor (IC50 = 0.009 µM); selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM, respectively) and 24 additional lipid and protein kinases in a panel (IC50s = >50 µM for all); decreases phosphorylation of Akt and S6K1 in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells (IC50s = 0.6-2.5 µM); reduces tumor growth in a HepG2 mouse xenograft model at 10 mg/kg for 14 days

Formal name: 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

Synonyms: 

Molecular weight: 494.6

CAS: 1062159-35-6

Purity: ≥98%

Formulation: A solid

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