Description
An mTOR inhibitor (IC50 = 0.009 µM); selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM, respectively) and 24 additional lipid and protein kinases in a panel (IC50s = >50 µM for all); decreases phosphorylation of Akt and S6K1 in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells (IC50s = 0.6-2.5 µM); reduces tumor growth in a HepG2 mouse xenograft model at 10 mg/kg for 14 days
Formal name: 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
Synonyms:
Molecular weight: 494.6
CAS: 1062159-35-6
Purity: ≥98%
Formulation: A solid
