Inactive enantiomer of W146

W140 (trifluoroacetate salt) – 5 mg

Brand:
Cayman
CAS:
909725-64-0
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material).{14254} It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.  

 

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SKU: 10009110 - 5 mg Category:

Description

Inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM; exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146

Formal name: [3S-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)

Synonyms: 

Molecular weight: 456.4

CAS: 909725-64-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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