A cell-permeable antagonist of calmodulin (Ki = 11 μM); also associates

W-7 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
61714-27-0
Storage:
-20
UN-No:
Non-Hazardous - /

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.{23723,23722} W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM).{23720,22382} Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins.{23720} W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).{23724,23721,23719}  

 

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Description

A cell-permeable antagonist of calmodulin (Ki = 11 μM); also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively)

Formal name: N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, monohydrochloride

Synonyms:  NSC 683545

Molecular weight: 377.3

CAS: 61714-27-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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