A less active

W-5 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
61714-25-8
Storage:
-20
UN-No:
Non-Hazardous - /

W-5 is a chlorine-deficient analog of W-7 (Item No. 14826), a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities (Ki = 11 μM).{22382,22380} W-5 is less active than its calmodulin antagonist counterpart, inhibiting CHO-K1, MCF-7 breast cancer, and human myeloid progenitor cell proliferation with IC50 values greater than 100 μM.{22382,22381,22383} As a weaker antagonist for calmodulin, W-5 is suitable for use as a control compound for understanding the specificity of other calmodulin antagonists.  

 

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Description

A less active, chlorine-deficient analog of W-7, the potent calmodulin antagonist (Ki = 11 μM); suitable for use as a control compound for understanding the specificity of other calmodulin antagonists

Formal name: N-(6-aminohexyl)-1-naphthalenesulfonamide, monohydrochloride

Synonyms: 

Molecular weight: 342.9

CAS: 61714-25-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|CaMK Signaling||Research Area|Cell Biology|Cell Signaling

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