A prodrug form of VRT-043198; inhibits LPS-induced increases in serum IL-1β levels in mice at 50

VX-765 – 25 mg

Brand:
Cayman
CAS:
273404-37-8
Storage:
-20
UN-No:
Non-Hazardous - /

VX-765 is a prodrug form of the caspase-1 inhibitor VRT-043198.{45582} VX-765 (50, 100, and 200 mg/kg) inhibits LPS-induced increases in serum IL-1β levels in mice. It also reduces oxazolone-induced ear edema and levels of IL-1β, IL-18, and IFN-γ in ear tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity. VX-765 reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner. VX-765 (≥50 mg/kg) decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection, as well as delays the onset of seizures when administered at doses of 100 and 200 mg/kg.{45583} It also reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy.  

 

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Description

A prodrug form of VRT-043198; inhibits LPS-induced increases in serum IL-1β levels in mice at 50, 100, and 200 mg/kg; reduces oxazolone-induced ear edema and levels of IL-1β, IL-18, and IFN-γ in ear tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity; reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner; decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection at ≥50 mg/kg, as well as delays the onset of seizures at 100 and 200 mg/kg; reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy

Formal name: N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide

Synonyms:  Belnacasan

Molecular weight: 509

CAS: 273404-37-8

Purity: ≥98%

Formulation: A crystalline solid

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