A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors

VUF10460 – 1 mg

Brand:
Cayman
CAS:
1028327-66-3
Storage:
-20
UN-No:
Non-Hazardous - /

VUF10460 is a histamine H4 receptor agonist (Kis = 5.01 and 14.13 nM for the human and rat receptors, respectively).{51084,51085} It is selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively).{51085} VUF10460 (10 mg/kg) potentiates the formation of HCl-induced ulcers in the rat gastric mucosa, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120 (Item No. 10011925).  

 

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Description

A histamine H4 receptor agonist (Kis = 5.01 and 14.13 for the human and rat receptors, respectively); selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively); potentiates the formation of HCl-induced ulcers in the rat gastric mucosa at 10 mg/kg, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120

Formal name: 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine

Synonyms: 

Molecular weight: 269.4

CAS: 1028327-66-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation

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