An adenosine A3 receptor antagonist (Ki = 4.03 nM for the recombinant human receptor); >2

VUF 5574 – 5 mg

Brand:
Cayman
CAS:
280570-45-8
Storage:
-20
UN-No:
Non-Hazardous - /

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor).{49476} It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine (Item No. 21232) in isolated porcine coronary artery smooth muscle cells.{49477} It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM.{49478} VUF 5574 (2 µg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.{49479}  

 

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SKU: 27676 - 5 mg Category:

Description

An adenosine A3 receptor antagonist (Ki = 4.03 nM for the recombinant human receptor); >2,500-fold selective for adenosine A3 over A1 and A2A receptors; decreases adenosine-induced phosphorylation of ERK1/2 in isolated porcine coronary artery smooth muscle cells at 100 nM; increases oxygen-glucose deprivation-induced reductions in the amplitude of field EPSPs in a rat hippocampal slice model of ischemia at 100 nM; reduces sodium nitroprusside-induced heart rate increases in rats at 2 µg intracisternally

Formal name: N-(2-methoxyphenyl)-N’-[2-(3-pyridinyl)-4-quinazolinyl]-urea

Synonyms: 

Molecular weight: 371.4

CAS: 280570-45-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Neuroscience|Neuroprotection|Ischemia

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