Description
A potent and selective agonist of M1 receptors (EC50 = 0.2 mM compared to >10 mM for M2-M5); induces concentration-dependent increases in Ca2+ mobilization and ERK1/2 phosphorylation in hM1 CHO cells (EC50s = 0.89 and 10 mM, respectively); improves hippocampal-dependent spatial learning and localization abilities and acquistion of contextual fear learning but cannot reverse amphetamine-induced hyperlocamotion in rats
Formal name: (3R)-3-[(2-methylbenzoyl)amino]-[1,4′-bipiperidine]-1′-carboxylic acid, ethyl ester, 2,2,2-trifluoroacetate
Synonyms:
Molecular weight: 487.5
CAS: 1240514-89-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory
