Description
A positive allosteric modulator of mGluR5 (Ki = 195 nM); selective for mGluR5 over mGluR1, mGluR3, and mGluR4 at 10 µM; prevents TNF-α and NO production by IFN-γ- or LPS-stimulated BV-2 and primary microglial cells at 20 and 50 µM; reduces expression of iNOS and increases expression of Ym1 and arginase 1 in LPS-stimulated BV-2 cells at 20 µM; reduces the size of cortical lesions, prevents hippocampal neurodegeneration, and improves sensorimotor deficits in the beam walk test in a mouse model of traumatic brain injury (TBI)
Formal name: N-cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide, monohydrochloride
Synonyms:
Molecular weight: 330.8
CAS: 1309976-62-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection
